Several processes kicked off during 2025 to reimagine the future of the global health architecture. They include:
Accra Reset
Launched by the President of Ghana, H.E. John Mahama, in the sidelines of the 80th United Nations General Assembly, the Accra Reset is an Africa-led initiative calling for a reimagined global health order that empowers nations to lead resilient and self-sustaining health responses. A Global Presidential Council – a coalition of heads of state and government from around the world – will provide political leadership to drive the Accra Reset’s agenda. The Accra Reset builds on the outcomes of the 5 August Africa Health Sovereignty Summit hosted by President Mahama in Accra that agreed that Africa must move from aid dependency to self-determination and fleshed out a process for reimagining a global health governance architecture in which Africa shares power and accountability.
European Union/Like-minded Donors Reflection Process
This European Commission-led process aims by the end of the end of 2025 to:
- support donors to strengthen alignment around a clear vision for global health and development priorities, roles and responsibilities, and opportunities and risks associated with reforming the current health architecture, and,
- produce an options paper to help EU/like-minded donors reflect on how to advance global health reform and participate constructively as a group in the wider global dialogue.
The process is guided by a reference group and expert group and includes key information interviews, consultation panels and an on-line survey and will eventually be brought to a more political level to consider the appetite for change and how to take the options forward.
HEAR CSO (Health Architecture Reimagined – Civil Society Organizations)
A civil society consortium led by WACI Health that includes the NCD Alliance, UHC2030 CSEM, ITPC, GNP+, StopAIDS UK and GFAN aims by July 2026 to ensure that civil society and communities are supported to develop and articulate their visions for the future of the global health ecosystem, including through existing and new processes looking at reforming the global health ecosystem to become more inclusive, equitable, and responsive to their needs. The process includes global, regional and national consultations as well as mapping and analysis of existing literature.
Check the HEAR CSO website for updates.
Sevilla Platform for Action – Global Health
A part of the Sevilla Platform for Action (SPA) launched at the IV International Conference on Financing for Development (FFD4), the initiative “Towards a Renewed Global Health Ecosystem: Navigating Challenges and Opportunities for Financing Inclusive, Resilient, and Sustainable Health Systems” aims to reform the global health architecture to be more cohesive, country-led, and aligned with sustainable financing strategies. This initiative, which builds on the Lusaka Agenda and ongoing reform dialogues, proposes a shared roadmap to strengthen health system resilience and equity without creating new mechanisms or institutions.
The initiative is structured around two key areas of action:
- Inviting relevant organizations and global health initiatives to propose concrete ideas of reform aimed at improving coherence, agility, efficiency, maximizing impact, strengthening collaboration, avoiding overlapping and fragmentation and supporting partner countries leadership with a view to presenting a joint reform roadmap by early 2026 with an accountability mechanism to the Boards.
- Renewing countries’ intention to support a restructured, more agile and coordinated global health ecosystem, with an emphasis on promoting universal health coverage through inclusive, resilient and sustainable national health systems.
Wellcome
Over the next year, Wellcome will be bringing together a wide range of voices to participate in multi-stakeholder conversations about what a new global health system should look like.
To kick-start the conversation, Wellcome has commissioned five thought leaders from across the world to share their visions for global health. These ambitious ideas are outlined in five discussion papers that will be used as the starting point for regional dialogues among stakeholders. This work is closely linked to Wellcome’s wider ongoing work on the Lusaka Agenda.
Op-ed in Nature Medicine, 11 September 2025